New PDF release: Analytical Profiles of Drug Substances and Excipients, Vol.

By Harry G. Brittain

ISBN-10: 0122608283

ISBN-13: 9780122608285

Even if the respectable compendia outline a drug substance by way of its identification, purity, power, and caliber, they often don't offer different actual or chemical information, nor do they record equipment of synthesis or pathways of actual or organic degradation and metabolism. Such details is scattered in the course of the clinical literature and the records of pharmaceutical laboratories.Edited by means of the affiliate Director of Analytical learn and improvement for the yankee organization of Pharmaceutical Scientists, Analytical Profiles of Drug ingredients and Excipients brings this knowledge jointly in a single resource. The scope of the sequence has lately been accelerated to incorporate profiles of excipient fabrics.

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3 Methods of the British and Indian Pharmacopoeias According to the British [7] and Indian [9] Pharmacopoeias, about 550 mg of analyte is accurately weighed and dissolved in 50 mL of water, or an accurately weighed of 2 g of analyte is dissolved in 100 mL of water. Each solution is titrated with 1 M sodium hydroxide using phenolphthalein solution as the indicator. 03 mg of citric acid. 4 Potentiometric Titration In this method, the position of the endpoint is determined to a potentiometric endpoint, and an indicator substance is not used.

3 Methods of the British and Indian Pharmacopoeias According to the British [7] and Indian [9] Pharmacopoeias, about 550 mg of analyte is accurately weighed and dissolved in 50 mL of water, or an accurately weighed of 2 g of analyte is dissolved in 100 mL of water. Each solution is titrated with 1 M sodium hydroxide using phenolphthalein solution as the indicator. 03 mg of citric acid. 4 Potentiometric Titration In this method, the position of the endpoint is determined to a potentiometric endpoint, and an indicator substance is not used.

G. 3 High Performance Liquid Chromatography A food analysis handbook cited that citric acid can be determined by HPLC using reverse phase ion exchange and on proprietary columns for organic acids [56]. There is also an issue [61] that describes a liquid chromatographic assay for citric acid in over the counter carbamide peroxide products that uses indirect UV detection. The AOAC Official Method describes the determination of quinic, malic. and citric acids in cranberry juice cocktail and apple juice by two reverse phase liquid chromatography columns in tandem [55].

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Analytical Profiles of Drug Substances and Excipients, Vol. 28 by Harry G. Brittain


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