By Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings
This quantity serves as a development file on state-of-the-art examine within the box of Alzheimer's disorder and other kinds of dementia, yet with an emphasis on subject matters which are acceptable to scientific perform. during this most modern installment, Serge Gauthier, Philip Scheltens and Jeffrey Cummings conceal many of the rising treatments for Alzheimer's ailment, together with statins, GAG minetics, and immunotherapy, in addition to using hormonal remedy and extraordinary anti-psychotic brokers within the remedy of alternative similar dementias. Chapters also will summarize the present realizing of the pathophysiology of light cognitive impairment in addition to study into tau pathologies.
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Extra info for Alzheimer's Disease and Related Disorders Annual 5
Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer’s disease. Ann Neurol 2001;50: 150–156. Kohnken R, Buerger K, Zinkowski R, et al. Detection of tau phosphorylated at threonine 231 in cerebrospinal fluid of Alzheimer’s disease patients. Neurosci Lett 2000;287:187–190. Parnetti L, Lanari A, Amici S, et al. CSF phosphorylated tau is a possible marker for discriminating Alzheimer’s disease from dementia with Lewy bodies.
30,49 In one study it has been shown that the combination of CSF Aβ42 with Ptau-181 differentiated best early onset AD (EAD) from FTD with a high specificity (93%) and a low negative predictive 82 probable AD 74 NAD 150 probable AD 79 NAD 80 probable AD 41 definite AD 27 NAD 105 probable AD 23 VAD 9 DLB 74 probable AD 34 FTLD 49 probable AD 15 NAD 6 VAD 47 probable EAD 28 FTLD Galasko et al, 199822 c b a Clinical diagnosis (1A) Clinical diagnosis (1A) Clinical diagnosis (1A) NINCDS–ADRDA VAD: NINDS–AIREN DLB: McKeith NINCDS–ADRDA FTLD: Neary NINCDS–ADRDA VAD: NINDS–AIREN AD vs NAD/VAD: NINCDS–ADRDA FTLD: Neary NINCDS–ADRDA CERAD Sensitivity: 71–90% Specificity: 83–100% Sensitivity 72% Specificity 89% Sensitivity 94% Specificity VAD 48% Specificity DLB 67% Sensitivity 85% Specificity 85% Sensitivity 77% Specificity 65% Sensitivity 85% Specificity 58% Sensitivity 50% Specificity 85% Result Aβ42: 528 pg/ml Tau: 432 pg/ml AD vs NAD: Aβ42 : 435 pg/ml Tau : 437 pg/ml Aβ42 : 413 pg/ml Tau: 377 pg/ml Aβ42: 643 pg/ml Tau: 252 pg/ml Aβ42: 1032 pg/ml Tau: 503 pg/ml Aβ42: 643 pg/ml Tau: 252 pg/ml Aβ42 : 340 pg/ml Tau: 380 pg/ml Cut off Probable AD = AD according to the clinical NINCDS–ADRDA criteria; definite AD = AD confirmed at neuropathologic examination; EAD = early-onset AD, disease starting before 65 years old; VAD = vascular dementia; DLB = diffuse Lewy body disease; FTLD = frontotemporal lobar degeneration; NAD = non-Alzheimer dementia.
56. 57. 58. 59. 60. 61. 62. related dementias. Arch Neurol 1994;51:888–895. Varma AR, Snowden JS, Lloyd JJ, et al. Evaluation of the NINCDS–ADRDA criteria in the differentiation of Alzheimer’s disease and frontotemporal dementia. J Neurol Neurosurg Psychiatry 1999; 66:184–188. Jellinger KA. Diagnostic accuracy of Alzheimer’s disease: a clinicopathological study. Acta Neuropath 1996;91:219–220. Clark CM, Xie S, Chittams J, et al. Cerebrospinal fluid tau and betaamyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?
Alzheimer's Disease and Related Disorders Annual 5 by Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings