By Phyllis R. Brown, Eli Grushka
An up to date reference, offering an leading edge viewpoint on breakthroughs in separation technology, similar to reverse-phase HPLC, advances in hyphenation, and linear dependence of relative retention values at the nature of the provider fuel and standard column strain in gas-liquid chromatography.
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Additional resources for Advances in Chromatography: Volume 41
Reprinted with permission from Ref. S. Environmental Protection Agency) was isocratically separated in under 10 min. With detection in a packed section of the capillary, Ͼ700,000 plates/m were obtained. Lu¨dtke et al.  were the first to employ packings of submicrometer material in CEC. 5–4]. One possible explanation for this result is the fact that the B term of the plate-height equation [see Eq. 4] is not dependent on the particle diameter. Knox  has predicted that, using submicrometer material, all contributions from the A and C terms of the plate-height equation become insignificant compared to the band-broadening process, due to axial diffusion.
Assuming that with a strong cation exchanger the electroosmotic velocity will be high even at low pH, Smith and Evans  tested the separation of basic drugs by CEC at low pH with a strong cation exchanger as stationary phase, with unexpected results (see Fig. 9). The ion exchanger was Fundamentals of Capillary Electrochromatography / 31 made specifically for CEC, based on a specially prepared silica gel (dp ϭ 3 µm) onto which is bonded a propyl sulfonate group. In order to make it possible to perform reversed-phase CEC with relatively high electroosmotic velocity quasi-independent of the pH, Zhang and El Rassi  introduced a novel silica-based multilayered stationary phase.
Other workers used a miniaturized titration device for gradient CEC [116,146]. Also, voltage programming is reported as an alternative to mobile-phase composition gradient programming . It has to be emphasized, however, that this technique is of limited applicability, as no variation in the retention factor is achieved by voltage gradients. V. MOBILE-PHASE CONSIDERATIONS Not only surface properties of the stationary phase but also bulk properties of the mobile phase determine the electroosmotic mobility in the chromatographic bed.
Advances in Chromatography: Volume 41 by Phyllis R. Brown, Eli Grushka