Advances in Chromatographic Techniques for Therapeutic Drug by Amitava Dasgupta PDF

By Amitava Dasgupta

ISBN-10: 1420067583

ISBN-13: 9781420067583

For medications with a slim healing index, healing drug tracking equipment are crucial for sufferer administration. even though immunoassays are commercially on hand for lots of medications and so much laboratories use those assays for regimen healing tracking, they've got many barriers which prevent their efficacy. delivering useful instructions for enforcing hottest gasoline and liquid chromatographic equipment, Advances in Chromatographic recommendations for healing Drug tracking is a finished reference describing the idea and alertness of healing drug tracking in medical laboratories. Edited by means of a special authority within the box and containing contributions from numerous specialists, the publication discusses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, matters on the topic of soreness administration and natural vitamins, and healing drug tracking for various medicines, together with: Anticonvulsants Digitalis Cardioactive medications Antidepressants Immunosuppressants Anti-cancer medicinal drugs Vancomycin and aminoglycosides Antibiotics Antiretroviral medicines Nonnarcotic analgesics anti inflammatory medicines ? Examing older and more moderen medicinal drugs, the e-book includes certain discussions at the intent for healing drug tracking of every type of gear, in addition to their uncomplicated pharmacology and toxicology. an in depth record of references is supplied on the finish of every bankruptcy in order that these attracted to enforcing a brand new drug assay can locate the main applicable process for the meant drug.

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However, nevirapine half-life is significantly prolonged in pregnancy. For protease inhibitors, reduction of maximum plasma concentration of indinavir was observed in pregnancy. This may be due to induction of cytochrome P450. Standard adult doses of nelfinavir and saquinavir produced lower drug concentration in HIV-infected pregnant women compared to nonpregnant women [61]. During pregnancy the thyroid is hyper-stimulated resulting in changes in thyroid hormone concentrations. Gestational age-specific reference intervals are now available for thyroid function tests.

For example, St John’s wort induces cytochrome P450 resulting in a lower plasma concentration of many drugs due to increased metabolism (see Chapter 22). Phenotyping procedures commonly involve administration of a probe drug and calculating the urine or plasma metabolic ratio. Traditional therapeutic drug monitoring is useful for phenotyping and can be used to identify slow as well as fast metabolizers, the pharmacogenomics approach to personalized medicine is based on the utilization of genetic information data in pharmacotherapy and drug delivery thus ensuring better drug efficacy and safety in patient management.

Pharmacodynamic drug interactions in smokers may be due to nicotine, which may counteract the pharmacological effects of a drug. Smokers taking benzodiazepines, such as diazepam and chlordiazepoxide experience less drowsiness than nonsmokers and this interaction appears to be pharmacodynamic in nature because several studies did not find any significant difference between metabolism of benzodiazepines between smokers and nonsmokers. Therefore, larger doses may be needed to sedate a smoker [76].

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Advances in Chromatographic Techniques for Therapeutic Drug Monitoring by Amitava Dasgupta


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