By J.K. Aronson (Eds.)
Quantity 28 within the sequence of uncomfortable side effects of gear Annuals (http://www.elsevier.com/locate/series/seda) maintains to serve its fundamental target: to supply clinicians and clinical investigators with a competent and demanding every year survey of latest information and traits within the quarter of difficult Drug Reactions and Interactions. a global staff of experts has reviewed new facts and traits via picking out from the year's writing all that's really new and informative, via seriously studying it, and via pointing to no matter what is unproven or deceptive. using the ebook is stronger via separate indexes, permitting the reader to entry the textual content through drug identify, opposed impression, or drug interplay. the present annual contains an essay by way of the editor, Dr Jeffrey Aronson, entitled 'Classifying Drug antagonistic Reactions within the twenty first Century.' In it he describes how the trendy method of classifying opposed drug reactions takes under consideration the dose that motives the response, the time-course of the response, and the susceptibility elements that elevate the person patient's hazard, and indicates how this research can facilitate regulatory selection making. *Provides a severe each year survey of latest facts and trends*Includes an essay that describes the fashionable method of classifying adversarial drug reactions*Special experiences during this Annual contain, between different subject matters: Antipsychotic medicinal drugs and now-onset diabetes mellitus, Treating bronchial asthma while pregnant, and MMR vaccine and autism
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Additional info for A worldwide yearly survey of new data and trends in adverse drug reactions
4 Pregnancy Considering the increased prevalence of recreational cocaine abuse among young women (37rc ), the diverse clinical manifestations of acute cocaine intake combined with physiological changes of pregnancy and the pathophysiology of co-existing pregnancyspecific diseases can result in life-threatening complications during anesthesia. When regional anesthesia is selected, combative behaviour, altered pain perception, and ephedrine-resistant hypotension can occur. Cardiac dysrhythmias, hypertension, and myocardial ischemia can occur during general anesthesia.
A 26-year-old woman with a history of multiple substance abuse required emergency caesarean section at 30 weeks of gestation as a result of crack cocaine-induced placental abruption and fetal distress (38c ). Her admission blood pressure was 145/95 mmHg, heart rate 95/minute and respiratory rate 20/minute. The fetal heart rate was 130/minute and non-reactive, with late and variable decelerations and no response to maternal oxygen administration. Spinal block with bupivacaine, fentanyl, and morphine was performed with the patient in a sitting position.
Kanda T, Yokosuka O, Tada M, Kurihara T, Yoshida S, Suzuki Y, Nagao K, Saisho H. N-Nitroso-fenfluramine hepatotoxicity resembling chronic hepatitis. J Gastroenterol Hepatol 2003; 18: 999–1000. 75. Pilsczek FH, Karcic AA, Freeman I. Case report: Dexatrim (phenylpropanolamine) as a cause of myocardial infarction. Heart Lung 2003; 32: 100–4. 76. Oosterbaan R, Burns MJ. Myocardial infarction associated with phenylpropanolamine. J Emerg Med 2000; 18: 55–9. 77. Anonymous. French Agency for Health Product Safety press release.
A worldwide yearly survey of new data and trends in adverse drug reactions by J.K. Aronson (Eds.)