New PDF release: A Handbook for DNA-Encoded Chemistry: Theory and

By Robert A. Goodnow Jr.

ISBN-10: 1118487680

ISBN-13: 9781118487686

This publication comprehensively describes the improvement and perform of DNA-encoded library synthesis know-how. jointly, the chapters element an method of drug discovery that gives an enticing addition to the portfolio of current hit iteration applied sciences akin to high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

  • Provides a precious advisor for figuring out and making use of DNA-encoded combinatorial chemistry
  • Helps chemists generate and monitor novel chemical libraries of enormous dimension and caliber
  • Bridges interdisciplinary components of DNA-encoded combinatorial chemistry – artificial and analytical chemistry, molecular biology, informatics, and biochemistry
  • Shows medicinal and pharmaceutical chemists the best way to successfully increase on hand “chemical area” for drug discovery
  • Provides specialist and updated precis of pronounced literature for DNA-encoded and DNA-directed chemistry expertise and methods

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Extra resources for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery

Example text

For short nucleotide repeats, up to six nucleotides, there is a direct proportionality between the number of nucleotides incorporated and the intensity of the bioluminescence signal. However, longer nucleotide repeats may result in insertion and deletion errors as in such cases the number of nucleotides cannot be easily deduced from the intensity of light. DNA sequencing technologies are still rapidly expanding and improving, resulting in increased speed and capacity with reduction of cost. They greatly accelerate progress in biomedical research, forensics, agriculture, and diagnostics and enable novel technologies such as DEL.

Agarose gels can be prepared and poured in the lab prior to use. Alternatively, precast gels, both denaturing and native polyacrylamide and agarose, can be purchased from commercial vendors. DNA Sequencing 13 DNA on a gel is not visible to the human eye, and thus, it needs to be stained or otherwise rendered visible in order to be detected. Ethidium bromide is widely used for the visualization of double-stranded DNA. It works by intercalating into the DNA duplex and fluorescing under UV light, revealing the localization of the DNA bands on a gel.

Whereas a nucleotide is phosphorylated at the 5′-hydroxyl group, a nucleoside has a free 5′-hydroxyl. All natural DNA nucleosides have β-configuration at the anomeric carbon. 2). One-letter abbreviations A, G, C, and T are commonly used to denote these moieties. 1. Generic structure of a 2-deoxy-2-d-ribose nucleotide. 2. DNA bases. 3. Structure of AGTT. , while numbers without prime notation are used for atoms in bases. Phosphodiester bonds link 3′- and 5′-hydroxyl groups of neighboring 2-deoxy-d-ribose molecules, forming a DNA backbone.

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A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery by Robert A. Goodnow Jr.

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